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Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 6, 784-788.
doi: 10.1302/0301-620X.91B6.21853  
Copyright © 2009 by British Editorial Society of Bone and Joint Surgery
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The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma

M. Kaya, MD, Assistant Professor1; T. Wada, MD, Associate Professor1; S. Nagoya, MD, Associate Professor1; M. Sasaki, MD, Orthopaedic Surgeon1; T. Matsumura, MD, Orthopaedic Surgeon1; and T. Yamashita, MD, Professor and Director1

1 Department of Orthopaedic Surgery Sapporo Medical University, School of Medicine, S-1 W-16, Chuo-ku, Sapporo 060-8543, Japan.

Correspondence should be sent to Professor M. Kaya; e-mail: mkaya{at}sapmed.ac.jp

We undertook a prospective study to evaluate the prognostic significance of the serum levels of vascular endothelial growth factor (VEGF) in predicting the survival of patients with osteosarcoma. The levels were measured by an enzyme-linked immunosorbent assay in 15 patients with osteosarcoma before commencing treatment. The patients were divided into two groups, with a high or a low serum VEGF level, and the incidence of metastases and overall survival rate were compared.

No significant relationship was observed between the serum VEGF levels and gender, age, the size of the tumour or the response to pre-operative chemotherapy. Patients with a serum VEGF > 1000 pg/ml had significantly worse survival than those with a level < 1000 pg/ml (p = 0.002). The serum VEGF level may be useful in predicting the prognosis for survival in patients with osteosarcoma.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General