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Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 8, 1106-1109.
doi: 10.1302/0301-620X.91B8.22216  
Copyright © 2009 by British Editorial Society of Bone and Joint Surgery
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Locally-administered antibiotics in wounds in a limb

J. G. Branstetter, BS, MD, Orthopaedic Surgeon1; S. R. Jackson, BSE, MS, Graduate Student2; W. O. Haggard, BS, MS, PhD, Professor of Biomedical Engineering3; K. C. Richelsoph, BS, MS, Project Engineer4; and J. C. Wenke, BS, MS, PhD, Manager, Extremity Trauma & Regenerative Medicine Task Area1

1 3400 Rawley East Chambers Avenue, San Antonio, Texas 78234, USA.
2 St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA.
3 Department of Biomedical Engineering, 330 Engineering Technology University of Memphis, Memphis, Tennessee 38152, USA.
4 Intelligent Implant Systems, LLC 3300 International Airport Drive, Suite 1100, Charlotte, North Carolina 28208, USA.

Correspondence should be sent to Dr J. C. Wenke; e-mail: Joseph.Wenke{at}us.army.mil

We used a goat model of a contaminated musculoskeletal defect to determine the effectiveness of rapidly-resorbing calcium-sulphate pellets containing amikacin to reduce the local bacterial count. Our findings showed that this treatment eradicated the bacteria quickly, performed as well as standard polymethylmethacrylate mixed with an antibiotic and had many advantages over the latter. The pellets were prepared before surgery and absorbed completely. They released all of the antibiotic and did not require a subsequent operation for their removal. Our study indicated that locally administered antibiotics reduced bacteria within the wound rapidly. This method of treatment may have an important role in decreasing the rate of infection in contaminated wounds.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General