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Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 8, 997-1006.
doi: 10.1302/0301-620X.91B8.21824  
Copyright © 2009 by British Editorial Society of Bone and Joint Surgery
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An overview of autologous chondrocyte implantation

P. D. Gikas, BSc (Hons), MBBS (Hons), MRCS, Specialist Registrar1; L. Bayliss, MRCS, Specialist Registrar1; G. Bentley, DSc, ChM, FRCS, FMedSci, Professor1; and T. W. R. Briggs, MCh(Orth), FRCS(Orth), Consultant Orthopaedic Surgeon and Joint Reconstruction Unit1

1 Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.

Correspondence should be sent to Mr P. D. Gikas; e-mail: pdgikas{at}doctors.org.uk

Chondral damage to the knee is common and, if left untreated, can proceed to degenerative osteoarthritis. In symptomatic patients established methods of management rely on the formation of fibrocartilage which has poor resistance to shear forces. The formation of hyaline or hyaline-like cartilage may be induced by implanting autologous, cultured chondrocytes into the chondral or osteochondral defect.

Autologous chondrocyte implantation may be used for full-thickness chondral or osteochondral injuries which are painful and debilitating with the aim of replacing damaged cartilage with hyaline or hyaline-like cartilage, leading to improved function. The intermediate and long-term functional and clinical results are promising.

We provide a review of autologous chondrocyte implantation and describe our experience with the technique at our institution with a mean follow-up of 32 months (1 to 9 years).

The procedure is shown to offer statistically significant improvement with advantages over other methods of management of chondral defects.




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P. D. Gikas, T. Morris, R. Carrington, J. Skinner, G. Bentley, and T. Briggs
A correlation between the timing of biopsy after autologous chondrocyte implantation and the histological appearance
J Bone Joint Surg Br, September 1, 2009; 91-B(9): 1172 - 1177.
[Abstract] [Full Text] [PDF]


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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General