Sir,
I read this paper with interest. The authors
have reviewed several publications that looked at the use of various
antiseptic solutions which included povidone iodine, chlorhexidine
gluconate, hydrogen peroxide and sodium hypochlorite. The use of aqueous
chlorhexidine in 4% and in 0.05% concentrations have been studied by Goebel et al1 and Taylor et al,2
and the authors have found them effective in clearing bacterial
contamination in in-vivo and in-vitro models of wound contamination.
Taylor et al have reviewed the effectiveness and toxic effects and found
chlorhexidine gluconate in 0.05% to be effective in clearing
bacterial contamination and non toxic to soft tissues and wound
healing. They recommended chlorhexidine should not be used on the brain,
meninges, middle ear and articular surfaces. The use of aqueous
chlorhexidine gluconate or acetate (0.05%) in irrigating open fractures
(not involving a joint) followed by isotonic saline needs consideration.
K.C. Kong,
Consultant Orthopaedic Surgeon,
King George Hospital,
Ilford, UK.
1. Goebel ME, Drez D, Heck SB, Stoma MK.
Contaminated rabbit patellar tendon grafts. In vivo analysis of
disinfecting methods. Am J Sports Med 1994;22:387-91.
2. Taylor GJ, Leeming JP, Bannister GC. Effect of antiseptics,
ultraviolet light and lavage on airborne bacteria in a model wound. J Bone
Joint Surg [Br] 1993;75-B:724-30.