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Oncology: G. Bacci, A. Balladelli, C. Forni, A. Longhi, M. Serra, N. Fabbri, M. Alberghini, S. Ferrari, M. S. Benassi, and P. Picci Ewing’s sarcoma family tumours: DIFFERENCES IN CLINICOPATHOLOGICAL CHARACTERISTICS AT PRESENTATION BETWEEN LOCALISED AND METASTATIC TUMOURS J Bone Joint Surg Br 2007; 89-B: 1229-1233 [Abstract] [Full text] [PDF]

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Serum lactic dehydrogenase as a prognostic factor of Ewing sarcoma family tumours outcome

Charalampos P. Dokos, Athanassios Tragiannidis, Fani Athanassiadou-Piperopoulou   (22 July 2009)

Serum lactic dehydrogenase as a prognostic factor of Ewing sarcoma family tumours outcome 22 July 2009
Charalampos P. Dokos, MD Hematology-Oncology Unit, 2nd Pediatrics Department, Aristotle University, Thessaloniki, Greece, Athanassios Tragiannidis, Fani Athanassiadou-Piperopoulou Send letter to journal: Re: Serum lactic dehydrogenase as a prognostic factor of Ewing sarcoma family tumours outcome dokos1984{at}yahoo.gr Charalampos P. Dokos, et al.	Sir, It was a great pleasure to read the interesting clinical study by Bacci et al concerning Ewing’s sarcoma family tumours (ESFT) and the differences in clinicopathological characteristics at presentation between localised and metatastatic tumours. We would like to share our experience in treating patients with ESFT in the 2nd Pediatric Hematology-Oncology Unit and confirm that a high level of serum lactic dehydrogenase (LDH) is related to poor prognosis and a prolonged chemotherapy period. LDH seems to be an important biomarker of survival for patients with an ESFT. We would like to have the authors’ opinion about the minimum serum LDH level that is considered to be a poor prognostic factor for survival and outcome after chemotherapy. Is a high serum LDH level correlated with the biological characteristics of ESFT or with genetic and epigenetic factors of the hosts? C.P. Dokos, MD, A. Tragiannidis, F. Athanassiadou-Piperopoulou, Hematology-Oncology Unit, 2nd Pediatrics Department, Aristotle University, Thessaloniki, Greece.