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<title>Journal of Bone and Joint Surgery - British Volume Arthroplasty</title>
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<title>Journal of Bone and Joint Surgery - British Volume</title>
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<title><![CDATA[[Arthroplasty] Pre-operative injections of epoetin-{alpha} versus post-operative retransfusion of autologous shed blood in total hip and knee replacement: A PROSPECTIVE RANDOMISED CLINICAL TRIAL]]></title>
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<p>This prospective randomised clinical trial evaluated the effect of alternatives for allogeneic blood transfusions after total hip replacement and total knee replacement in patients with pre-operative haemoglobin levels between 10.0 g/dl and 13.0 g/dl. A total of 100 patients were randomly allocated to the Eprex (pre-operative injections of epoetin) or Bellovac groups (post-operative retransfusion of shed blood). Allogeneic blood transfusions were administered according to hospital policy.</p>
<p>In the Eprex group, 4% of the patients (two patients) received at least one allogeneic blood transfusion. In the Bellovac group, where a mean 216 ml (0 to 700) shed blood was retransfused, 28% (14 patients) required the allogeneic transfusion (p = 0.002). When comparing Eprex with Bellovac in total hip replacement, the percentages were 7% (two of 30 patients) and 30% (nine of 30 patients) (p = 0.047) respectively, whereas in total knee replacement, the percentages were 0% (0 of 20 patients) and 25% (five of 20 patients) respectively (p = 0.042).</p>
<p>Pre-operative epoetin injections are more effective but more costly in reducing the need for allogeneic blood transfusions in mildly anaemic patients than post-operative retransfusion of autologous blood.</p>
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<dc:creator><![CDATA[Moonen, A. F. C. M., Thomassen, B. J. W., Knoors, N. T., van Os, J. J., Verburg, A. D., Pilot, P.]]></dc:creator>
<dc:date>2008-07-31</dc:date>
<dc:identifier>info:doi/10.1302/0301-620X.90B8.20595</dc:identifier>
<dc:title><![CDATA[[Arthroplasty] Pre-operative injections of epoetin-{alpha} versus post-operative retransfusion of autologous shed blood in total hip and knee replacement: A PROSPECTIVE RANDOMISED CLINICAL TRIAL]]></dc:title>
<dc:publisher>British Editorial Society of Bone and Joint Surgery</dc:publisher>
<prism:number>8</prism:number>
<prism:volume>90-B</prism:volume>
<prism:endingPage>1083</prism:endingPage>
<prism:publicationDate>2008-08-01</prism:publicationDate>
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